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Publications

  1. Stathopoulos C., Kalpaxis D. L., and Drainas D. (1995) Partial purification and characterization of RNase Ρ from Dictyostelium discoideum. Eur J Biochem 228: 976-980.
  2. Tekos A., Stathopoulos C., and Drainas D. (1998) Bimodal action of the alkaline earth cations on Dictyostelium discoideum ribonuclease Ρ activity. Biochemistry 37: 15474-15480.
  3. Tekos A., Tsagla A., Stathopoulos C., and Drainas D. (1999) Inhibition of Dictyostelium discoideum ribonuclease Ρ activity by aminoglycosides. Nucleic Acids Symp Series 41: 152-154
  4. Tumbula D., Vothknecht U.C., Kirn H., Ibba M., Min B., Li T., Pelaschier J., Stathopoulos C., Becker H. D. and Söll D. (1999) Archaeal aminoacyl-tRNA synthesis: diversity replaces dogma. Genetics 152: 1269-1276.
  5. Li T., Graham D. E., Stathopoulos C.,Haney P.J., Kirn H., Vothknecht U.C., Kitabatake M., Hong K., Eggertsson G., Curnow A.W., Lin W., Celic I., Whitman W. and Söll D. (1999) Cysteinyl-tRNA formation: the last puzzle of aminoacyl-tRNA synthesis. FEBS Letters 462: 302-306.
  6. Papadimou Ε., Monastirli A., Stathopoulos C., Tsambaos D., and Drainas D. (2000) Modulation of ribonuclease Ρ activity by calcipotriol. Eur J Biochem 267: 1173-1177.
  7. Stathopoulos C., Tsagla A., Tekos A., and Drainas D. (2000) Effect of peptidyltransferase inhibitors on ribonuclease Ρ activity from Dictyostelium discoideum. Mol Biol Reports 27: 107-111.
  8. Tekos A., Tsagla A., Stathopoulos C. and Drainas D. (2000) Inhibition of eukaryotic ribonuclease Ρ activity by aminoglycosides. Kinetic studies. FEBS Letters 485: 71-75.
  9. Stathopoulos C., Li T., Longman R., Vothknecht U.C., Becker H.D., Ibba M. and Söll D. (2000). One polypeptide with two aminoacyl-tRNA synthetase activities. Science 287: 479-482.
  10. Ibba M., Becker H. D., Stathopoulos C., Tumbula D. and Söll D. (2000) The adaptor hypothesis revisited. Trends Biochem Sci 25: 311-316.
  11. Bunjun S. (*), Stathopoulos C. (*), Graham D., Min B., Kitabatake M., Wang A.L., Wang   C.C., Vivares C.P., Weiss L.M. and Söll D. (2000) A dual-specificity aminoacyl-tRNA synthetase in the deep-rooted eukaryote Giardia lamblia. Proc Natl Acad Sci USA 97: 12997-13002. (*) first co-authors
  12. Stathopoulos C., Jacquin-Becker C., Becker H.D., Li T., Ambrogelly A., Longman R. and Söll D. (2001) Methanococcus jannaschii Prolyl-Cysteinyl-tRNA synthetase possesses overlapping amino acid binding sites. Biochemistry 40: 46-52.
  13. Stathopoulos C., Tekos A., Zarkadis, I. and Drainas D. (2001) Extensive deproteinization of Dictyostelium discoideum RNase Ρ reveals a new catalytic activity. Eur J Biochem 268: 2134-2140.
  14. Ibba M., Stathopoulos C. and Söll D. (2001). Protein Synthesis: 23 Amino acids and counting. Current Biology 11: 563-565.
  15. Ruan B., Ahel I., Ambrogelly A., Becker H. D., Bunjun S., Feng L., Tumbula D., Ibba M., Korencic D., Kobayashi H., Jacquin-Becker C., Mejlhede N., Min B., Raczniak G., Rinehart J., Stathopoulos C., Li T. and Söll D. (2001). Genomics and the evolution of aminoacyl-tRNA synthesis. Acta Biochim Pol 48: 313-321.
  16. Stathopoulos C., Kim W., Li T., Anderson I., Palioura S., Whitman W. and Söll D. (2001) Cysteinyl-tRNA synthetase is not essential for the viability of the archeaon Methanococcus maripaludis. Proc Natl Acad Sci USA 98: 14292-14297.
  17. Feng L., Stathopoulos C., Ahel I., Mitra A., Hartsch T., Tumbula D. and Söll D. (2002). Aminoacyl-tRNA formation in the hyperthermophile Themus thermophilus. Extremophiles 6: 167-174.
  18. Jacquin-Becker C., Ahel I., Ambrogelly A., Ruan B. Söll D. and Stathopoulos C. (2002) Cysteinyl-tRNA formation and prolyl-tRNA synthetase FEBS Letters 514: 34-36.
  19. Stathopoulos C., Ahel I., Ambrogelly A., Becker H., Bunjun S., Feng L., Herring S., Jacquin-Becker C., Kobayashi H., Korencic D., Krett B., Mejlhede N., Min B., Nakano H., Namgoong S., Polycarpo C., Raczniak G., Rinehart J., Rosas-Sandoval G., Ruan B., Sabina J., Sauerwald A., Toogood H., Tumbula-Hansen D., Ibba M. and Söll D. (2002). Aminoacyl-tRNA synthesis: a post-genome perspective. Cold Spring Harbor Symp Quant Biol Vol. LXVI 175-183.
  20. Ahel I., Stathopoulos C., Ambrogelly A., Sauerwald A., Toogood H., Hartsch T. and Söll D. (2002) Cysteine activation is an inherent property of prolyl-tRNA synthetases. J Biol Chem 277: 34743-34748.
  21. Ambrogelly A., Ahel I., Polycarpo C., Bunjun-Srihari S., Krett B., Jacquin-Becker C., Kohrer C., Stathopoulos C., RajBhandary U.L. and Söll D. (2002) Methanocaldococcus jannaschii prolyl-tRNA synthetase charges tRNAPro with cysteine. J Biol Chem 277: 34749-34754.
  22. Kalavrizioti D., Vourekas A., Tekos A., Stathopoulos C. and Drainas D. (2003) Kinetics of inhibition of ribonuclease P activity by peptidyl-transferase inhibitors Mol Biol Reports 30: 9-15.
  23. Kamtekar S., Kennedy D.W., Wang J., Stathopoulos C., Söll D. and Steitz, T.A. (2003) The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases. Proc Natl Acad Sci USA 100: 1673-1678.
  24. Korencic D., Ahel I., Schelert J., Sacher M., Ruan B., Stathopoulos C., Blum P., Ibba, M. and Söll D. (2004) A freestanding proofreading domain isrequired for protein synthesis quality control in archaea. Proc Natl Acad Sci USA 101: 10260-10265.
  25. Tekos A. (*), Stathopoulos C. (*), Tsambaos D. and Drainas D. (2004) RNase P: a screening system and molecular target for the development of new drugs. Curr Med Chem 11: 2979-2989. (*) first co-authors
  26. Ruan B., Bovee M.L., Sacher M., Stathopoulos C., Poralla K., Francklyn C.S. and Söll D. (2005) A unique hydrophobic cluster near the active site contributes to differences of borrelidin inhibition among threonyl-tRNA synthetases. J Biol Chem 280: 571-577.
  27. Ambrogelly A., Kamtekar S., Stathopoulos C., Kennedy D. and Söll D. (2005) Asymmetrical behavior of archaeal proly-tRNA synthetase FEBS Letters 579: 6017-6022.
  28. Kottaridi C., Bolanaki E., Mamuris Z., Stathopoulos C. and Markoulatos P. (2006) Molecular phylogeny of VP1, 2A and 2B genes of echovirus isolates: epidemiological linkage and observations on genetic variation Arch Virol 151: 1117-1132.
  29. Paximadi E., Karakasiliotis I., Mamuris Z., Stathopoulos C., Krikelis V. and Markoulatos P. (2006) Genomic analysis of recombinant Sabin clinical isolates Virus Genes 32: 203-210.
  30. Vourekas A., Kalavrizioti D., Stathopoulos C., (*) and Drainas D. (2006) Modulation of catalytic RNA biological activity by small molecule effectors. M Rev Med Chem 6: 971-978. (*) corresponding author
  31. Kalavrizioti D. Vourekas A., Stamatopoulou, V., Toumpeki C., Giannouli S., Stathopoulos C., (*) and Drainas D. (2006) RNA-mediated therapeutics: from gene inactivation to clinical application Curr Top Med Chem 6: 1737-1758. (*) corresponding author
  32. Bailly M., Giannouli S., Blaise M., Stathopoulos C. (*), Kern D and Becker H. D. (2006) A single tRNA base-pair mediates bacterial tRNA-dependent biosynthesis of asparargine. Nucleic Acids Res 34: 6083-6094. (*) correspondin gauthor
  33. Vourekas A., Kalavrizioti D., Tekos A., Zarkadis I., Stathopoulos C. (*) and Drainas D. (2007) A 40.7 kDa Rpp30/Rpp1 homologue is a protein subunit of Dictyostelium discoideum RNase P holoenzyme. Biochimie 89: 301-310. (*) corresponding author
  34. Stagos D., Spanou C., Margariti M., Stathopoulos C., Mamuris Z., Kazantzoglou G., Magiatis P. and Kouretas D. (2007) Cytogenetic effects of grape extracts (Vitis vinifera) and polyphenols on mitomycin C-induced SCEs in human blood lymphocytes. J Agric Food Chem 55: 5246-5252.
  35. Zifa E., Giannouli S., Theotokis P., Stamatis K., Mamuris Z. and Stathopoulos C. (*)(2007) Mitochondrial tRNA mutations: functional and clinical perturbations. RNA Biology 4: 38-66. (*) corresponding author
  36. Kontou M., Kristo I., Ikonomidis A., Maniatis A., Pournaras S. and Stathopoulos C. (*)(2007) Molecular cloning and biochemical characterization of VIM-12, a novel hybrid metallo-β-lactamase from a Klebsiella pneumoniae clinical isolate, reveals atypical substrate specificity. Biochemistry 46: 13170-13178. (*) corresponding author
  37. Stamatis C., Giannouli, S., Suchentrunk F., Sert H., Stathopoulos C. (*) and Mamuris Z. (2008) RecruitmentofmitochondrialtRNAgenesasauxiliary variability markersfor both intra- and inter-species analyses: the paradigm of brown hare (Lepus europaeus) Gene 410: 154-164. (*) corresponding author
  38. Zifa E., Theotokis P., Kaminari A., Maridaki H., Leze H., Petsiava E., Mamuris Z. and Stathopoulos C. (*) (2008) A novel G3337A mitochondrial ND1 mutation related to cardiomyopathy co-segregates with tRNALeu(CUN) A12308G and tRNAThr C15946T mutations. Mitochondrion 8: 229-236. (*) corresponding author
  39. Ikonomidis A., Michail G., Vasdeki A., Labrou M., Karavasilis V., Stathopoulos C., Maniatis A. and Pournaras S. (2008) In vitro and in vivo evaluation of oxacillin efficiency on mecA-positive oxacillin-susceptible Staphylococcus aureus. Antimicrob Agents Chem 52: 3905-3908.
  40. Balatsos N. A. A., Anastasakis D. and Stathopoulos C. (*) (2009) Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis. J Enz Inh Med Chem 24: 516-523. (*) corresponding author
  41. Giannouli S., Kyritsis A., Malissovas N., Becker H.D. and Stathopoulos C. (*) (2009) On the role of an unusual tRNAGly isoacceptor in Staphylococcus aureus. Biochimie 91: 344-351. (*) corresponding author
  42. Papatheodorou L.K., Malizos K.N., Poultisidis L.A., Hantes M.E., Giannouli S., Grafanaki K., Ioannou M.G., Koukoulis G. K., Protopappas V. C., Fotiadis D. I. and Stathopoulos C. (2009) Effect of transosseus application of low-intensity ultrasound at the tendon graft-bone interface healing: Gene expression and histological analysis in rabbits. Ultrasound Med Biol 35: 576-584.
  43. Balatsos N.A.A., Vlachakis D., Maragozidis P., Manta S., Anastasakis D., Kyritsis A., Vlassi M., Komiotis D. and Stathopoulos C. (*) (2009) Competitive inhibition of human poly(A)-specific ribonuclease (PARN) by synthetic fluoro-pyranosyl nucleosides. Biochemistry 48: 6044-6051. (*) corresponding author
  44. Giannouli S., Labrou M., Kyritsis A., Ikonomidis A., Pournaras S., Stathopoulos C. (*) and Tsakris A. (2010) Detection of mutations in FemXAB protein family in oxacillin-susceptible, mecA positive Staphylococcus aureus clinical isolates J Antimicrob Chemoth 65: 626-633. (*) corresponding author
  45. Balatsos N.A.A., Vlachakis D., Chatzigeorgiou V., Manta S., Komiotis D., Vlassi M. and Stathopoulos C. (*) (2012) Kinetic and in silico analysis of the slow-binding inhibition of human Poly(A)-Specific Ribonuclease (PARN) by novel nucleoside analogues. Biochimie 94: 214-221. (*) corresponding author
  46. Tsikrikonis G., Maniatis A.N., Labrou M., Ntokou E., Michail G., Daponte A., Stathopoulos C., Tsakris A. and Pournaras S. (2012) Differences in biofilm formation and virulence genes between clinical and fecal enterococcal isolates of human and animal origin. Microbial Pathogenesis 52: 336-343.
  47. Ntokou E., Stathopoulos C., Kristo I., Dimitroulia E., Labrou M., Makris D., Zakynhtinos E., Tsakris A. and Pournaras S. (2012) Intensive care unit outbreak caused by multiple clones of linezolid-resistant Enterococcus faecalis and Enterococcus faecium in a tertiary hospital. J Antimicrob Chemoth 67: 1819-1823.
  48. Balatsos N. A. A., Maragozidis P., Anastasakis D. and Stathopoulos C. (*) (2012) Modulation of poly(A)-specific ribonuclease (PARN): current knowledge and perspectives. Current Med Chem 19: 4838-4849. (*) corresponding author
  49. Vlachakis D., Pavlopoulou A., Tsiliki G., Komiotis D., Stathopoulos C. Balatsos N. and Kossida S. (2012) An intergraded in silico approach to design specific inhibitors targeting human poly(A)-specific ribonuclease. PLoS ONE 7: e51113.
  50. Karoulia Z., Nomikos M., Thanassoulas A., Papadopoulos G., Papadopoulou-Choli D., Nounessis G., Kontou M., Stathopoulos C. (*), and Leonidas D.D. (2013) Studies on the intramolecular interactions between the A1 and A2 domains of the von Willebrand factor. Protein and Peptide Lett 20: 131-140. (*) corresponding author
  51. Pournaras S., Köck R., Mossialos D., Mellmann A., Sakellaris V., Stathopoulos C., Friedrich A. W. and Tsakris A. (2013) Detection of a phylogenetically distinct IMP-type metallo-ß-lactamase, IMP-35, in a CC235 Pseudomonas aeruginosa from the Dutch-German border region (Euregio). J Antimicrob Chemoth 68: 1271-1276.
  52. Pournaras S., Ntokou E., Zarkotou O., Ranellou K., Themeli-Digalaki K., Stathopoulos C. and Tsakris A. (2013) Emergence of linezolid-dependent Staphylococcus epidermidis bloodstream isolates. Emerging Infect Dis 19: 129-132.
  53. Saad N. Y., Stamatopoulou V., Drainas D., Stathopoulos C. (*) and Becker H. D. (2013) Τwo-codon T-box riboswitch binding two tRNAs. Proc Natl Acad Sci USA 110: 12756-12761. (*) corresponding author
  54. Pournaras S., Stathopoulos C. and Tsakris A. (2013) Oxacillin-susceptible MRSA: could it become a successful MRSA type? Future Microbiology 8:1365-1367.
  55. Apostolidi M., Vourtsis D. J., Chasapis C. T., Stathopoulos C., Bentrop D. and Spyroulias G. (2014) ¹H, ¹⁵N, ¹³C assignment and secondary structure determination of two domains of La protein from D. discoideum. Biomol NMR Assign 8: 47-51.
  56. Kokkori S., Apostolidi M., Tsakris A., Pournaras S., Stathopoulos C. (*) and Dinos G. (2014) Linezolid-dependent structure and function adaptation of ribosomes from linezolid-dependent S. epidermidis. J Antimicrob Chemoth 58: 4651-4656. (*) corresponding author
  57. Argyriou A. I., Chasapis C. T., Apostolidi M., Konstantinidou P., Stathopoulos C., Bentrop D. and Spyroulias G. (2015) Solution NMR assignment and secondary structure determination of RRM2 domain of La protein from a lower eukaryote exhibiting identical structural organization with its human homolog. Biomol NMR Assign 9: 219-222.
  58. Chasapis C. T., Argyriou A. I., Apostolidi M., Konstantinidou P., Bentrop D., Stathopoulos C. and Spyroulias G. (2015) 1H, 13C and 15N backbone and side-chain resonance assignment of the La-RRM1 module of La protein from Dictyostelium discoideum. Biomol NMR Assign 9: 303-307.
  59. Karavassilis V., Zarkotou O., Panopoulou M., Kachrimanidou M., Digalaki K., Stylianakis A., Gennimata V., Ntokou E., Stathopoulos C., Tsakris A. and Pournaras S. (2015) Wide dissemination of linezolid-resistant Staphylococcus epidermidis in Greece is associated with a linezolid-dependent ST22 clone. J Antimicrob Chemoth 70: 1625-1629.
  60. Apostolidi M., Saad N. Y., Drainas D., Pournaras S., Becker H. D. and Stathopoulos C. (*) (2015) A glyS T-box riboswitch with species-specific structural features responding to both proteinogenic and non-proteinogenic tRNAGly isoacceptors. RNA 21: 1790-1806. (*) corresponding author (Cover Featured Article)
  61. Dailiana Z. H., Christou D. C., Grafanaki K., Ioannou M. G., Stathopoulos C., Malizos K. N. and Varitimidis S. (2016) Histological and biochemical evidence related to the collagen quality in torn rotator cuff tendons. Acta Orthopaedica Belgica 82: 179-188.
  62. Anastasakis D., Skeparnias I., Shaukat N-A., Grafanaki K., Kanellou A., Taraviras S., Papachristou D. J., Papakyriakou A. and Stathopoulos C. (*) (2016) Mammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early development. Nucleic Acids Res 44: 8908-8920. (*) corresponding author
  63. Chaliotis A., Vlastaridis P., Mossialos D., Ibba M., Becker H. D., Stathopoulos C. (*) and Amoutzias G. D. (2017) The complex evolutionary history of aminoacyl-tRNA synthetases. Nucleic Acids Res 45: 1059-1068. (*) corresponding author
  64. Skeparnias I., Anastasakis D., Shaukat N-A., Grafanaki K., and Stathopoulos C. (*)(2017) The expanding repertoire of deadenylases RNA Biology 7:1-6 (*) corresponding author
  65. Stamatopoulou V., Apostolidi M., Li S., Labrinou K., Papakyriakou A., Zhang J. and Stathopoulos C. (*) (2017) Direct modulation of T-box riboswitch controlled transcription by protein synthesis inhibitors. Nucleic Acids Res 45: 10242-10258. (*) corresponding author
  66. Grafanaki K., Anastasakis D., Kyriakopoulos G., Skeparnias I., Georgiou K. and Stathopoulos C. (*) (2019) Translation regulation in skin cancer from a tRNA point of view. Epigenomics 11: 215-245. (*) corresponding author
  67. Li S., Su Z., Lehmann J., Stamatopoulou V., Giarimoglou N., Henderson F.E., Fan L., Pintilie G.D., Zhang K., Chen M., Ludtke SJ., Wang YX., Stathopoulos C., Chiu W., Zhang J. (2019) Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions. Nat Struct Mol Biol. 12:1094-1105 Featured in News and Views article: T-Box RNA gets boxed by Weaver J.W. and Serganov A.
  68. Skeparnias I., Anastasakis A.I., Grafanaki K., Kyriakopoulos G., Alexopoulos P., Dougenis D., Scorilas A., Konctos C.K. and Stathopoulos C. (*) (2020) Contribution of miRNAs, tRNAs and tRFs to Aberrant Signaling and Translation Deregulation in Lung Cancer. Cancers 12:3056. (*) corresponding author
  69. Kaliatsi E.G., Argyriou A.I., Bouras G., Apostolidi M., Konstantinidou P., Shaukat A.N., Spyroulias G.A. and Stathopoulos C. (*) (2020) Functional and Structural Aspects of La Protein Overexression in Lung Cancer. J Mol Biol  432:166712. (*) corresponding author
  70. Kaliatsi E.G., Giarimoglou N., Stathopoulos C. and Stamatopoulou V. (2020) Non-Coding RNA-Driven regulation of rRNA Biogenesis. Int J Mol Sci 21: 9738

 

 

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